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La sibutramina e, in misura ancora maggiore, i suoi due metaboliti principali, sono potenti inibitori della ricaptazione della serotonina e della noradrenalina. Pur essendo un anoressizzante centrale, la sibutramina non induce james duncan perde peso aumenta il rilascio né di noradrenalina né di serotonina; questa differenza rispetto alla fenfluramina e alla dexfenfluramina costituisce elemento di relativa sicurezza sotto il profilo degli effetti indesiderati, effetti attribuiti, per queste ultime, alla maggiore disponibilità di serotonina in circolo.

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